Large-scale sequencing tests, including whole-exome and whole-genome sequencing, are rapidly moving into clinical use. Sequencing is already being used clinically to identify therapeutic opportunities for cancer patients who have run out of conventional treatment options, to help diagnose children with puzzling neurodevelopmental conditions, and to clarify appropriate drug choices and dosing in individuals. To evaluate and support clinical applications of these technologies, the National Human Genome Research Institute and National Cancer Institute have funded studies on clinical and research sequencing under (...) the Clinical Sequencing Exploratory Research program as well as studies on return of results. Most of these studies use sequencing in real-world clinical settings and collect data on both the application of sequencing and the impact of receiving genomic findings on study participants. They are occurring in the context of controversy over how to obtain consent for exome and genome sequencing. (shrink)

This article presents the Pilgrimage Model as a template for educators wishing to lead students on site-specific studies of engaged learning. During the 2015–2016 academic year, a group of Georgeto...

Determination of the structure of the nucleic acids involved inter alia identification of the ring atom of the purines to which ribose or deoxyribose was attached. This in turn depended on knowledge of the ring atoms that could be so substituted and hence that were bonded to replaceable hydrogens. In 1897 E. Fischer adopted a convention of depicting this hydrogen at position 7 of the purine ring, although he was aware that it was equally correct to depict it at position (...) 9. Many later workers apparently came to believe that the 7H structure was more than just a convention, and considered that the sugar was attached solely at position 7 and could not be attached to position 9. When evidence was presented in 1933 that the sugar was in fact attached to position 9, the force of this convention apparently was so strong that many were reluctant to accept this evidence. More than 20 years was required for complete acceptance of the new view, and Fischer's convention was still being used in other contexts until at least 1967. (shrink)

Conceptualism is the view that at least some perceptual representation is conceptual. This paper considers a prominent recent argument against Conceptualism due to Ned Block. Block’s argument appeals to patterns of color representation in infants, alleging that infants exhibit categorical perception of color while failing to deploy concepts of color categories. Accordingly, the perceptual representation of color categories in infancy must be non-conceptual. This argument is distinctive insofar as it threatens not only the view that all perception is conceptual, but (...) also views that restrict the Conceptualist thesis to perceptual categorization. However, I contend that it fails at two stages. Block’s arguments for the perceptual representation of color categories in infancy, and against color concept deployment in infancy, are unpersuasive. Thus, Block has not vanquished Conceptualism. I draw out implications for debates about the perception-cognition border and for the question of whether explicit categorization occurs in perception. (shrink)

Causal closure arguments against interactionist dualism are currently popular amongst physicalists. Such an argument appeals to some principles of the causal closure of the physical, together with certain other premises, to conclude that at least some mental events are identical with physical events. However, it is crucial to the success of any such argument that the physical causal closure principle to which it appeals is neither too strong nor too weak by certain standards. In this paper, it is argued that (...) various forms of naturalistic dualism, of an emergentist character, are consistent with the strongest physical causal closure principles that can plausibly be advocated. (shrink)

Non-Cartesian substance dualism maintains that persons or selves are distinct from their organic physical bodies and any parts of those bodies. It regards persons as ‘substances’ in their own right, but does not maintain that persons are necessarily separable from their bodies, in the sense of being capable of disembodied existence. In this paper, it is urged that NCSD is better equipped than either Cartesian dualism or standard forms of physicalism to explain the possibility of mental causation. A model of (...) mental causation adopting the NCSD perspective is proposed which, it is argued, is consistent with all that is currently known about the operations of the human central nervous system, including the brain. Physicalism, by contrast, seems ill-equipped to explain the distinctively intentional or teleological character of mental causation, because it effectively reduces all such causation to ‘blind’ physical causation at a neurological level. (shrink)

It is widely thought that there are limits to how things can perceptually appear to us. For instance, nothing can appear both square and circular, or both pure red and pure blue. Adam Pautz has dubbed such constraints “laws of appearance.” But if the laws of appearance obtain, then what explains them? Here I examine the prospects for an empirical explanation of the laws of appearance. First, I challenge extant empirical explanations that appeal purely to the format of perceptual representation. (...) I then develop a hybrid approach, on which the laws are explained not merely by format, but by two further factors: ecological constraints imposed by our environments, and computational constraints embodied by our perceptual systems. While the hybrid approach implies that the laws of appearance are contingent, I argue that this implication is empirically defensible, since even some of the most intuitively compelling laws have real-world counterexamples. (shrink)

A self or person does not appear to be identifiable with his or her organic body, nor with any part of it, such as the brain; and yet selves seem to be agents, capable of bringing about physical events as causal consequences of certain of their conscious mental states. How is this possible in a universe in which, it appears, every physical event has a sufficient cause which is wholly physical? The answer is that this is possible if a certain (...) kind of naturalistic dualism is true, according to which the conscious mental states of selves, although not identifiable with physical states of their brains, are emergent effects of prior physical causes. Moreover, mental causation on this model promises to explain certain aspects of physical behaviour which may appear arbitrary and coincidental from a purely physical point of view. (shrink)

Molyneux’s question asks whether a person born blind who has learned to identify shapes by touch could, if suddenly granted sight, immediately identify shapes visually. This question has often been used to structure discussions of whether there is a “rational connection” between sight and touch—whether it is possible to rationally doubt whether the same shape properties are both seen and felt. I distinguish two questions under this general heading. The first concerns, roughly, whether the visual and haptic perception of shape (...) is rationally connected in normally sighted perceivers. The second concerns, roughly, whether the visual and haptic perception of shape is rationally connected in all possible perceivers. I argue that real-world implementations of Molyneux’s question are irrelevant to the first question, but potentially relevant to the second. However, I also argue that the second question does not have the philosophical significance it is sometimes claimed to have. In particular, it cannot be used to adjudicate debates about whether the phenomenal character of perceptual experience is primarily determined “externally” by the worldly properties we perceive, or “internally” by physiological or functional properties of our brains. (shrink)

. Analitic Map where explained factors and conditions to facilitate and inhibit the supply development process as well as purchasing strategies, in integrated companies with supply chain management. The research explores the advantages of a supply development straegy in the business world. All common practices in supply development are identified for a succesful implementation, as well as inhibitors to cause failure. Finally comparing theses strategies according to comanies´wealth generating strategies.Keywords. Supplier development, supply chain management, logistics, value chainResumen. El estudio propone (...) un esquema analítico único e integrador, que busca explorar los principales factores que condicionan, facilitan e inhiben el desarrollo de proveedores como estrategia de compras en empresas integradas en una cadena de valor, a fin de que, en una segunda etapa, sea contrastado empíricamente. En este sentido, el estudio pretende explorar las ventajas del desarrollo de proveedores proponiendo un conjunto de variables de análisis fundamentales para una mejor comprensión de los beneficios y alcances de ésta práctica. Para ello se busca identificar en la literatura académica los principales factores que generan la necesidad de recurrir al desarrollo de proveedores, las prácticas de abastecimiento que favorecen una implementación exitosa y sostenible, y los factores inhibidores que limitan el logro de los objetivos esperados, convirtiéndose en un mecanismo válido de generación de valor.Palabras claves. desarrollo de proveedores, cadena de abastecimiento, compras estratégicas, cadena de valor. (shrink)

"This comprehensive volume - containing 27 chapters and contributions from six continents - presents and discusses key principles, perspectives, and practices of social learning in the context of sustainability. Social learning is explored from a range of fields challenged by sustainability including: organizational learning, environmental management and corporate social responsibility; multi-stakeholder governance; education, learning and educational psychology; multiple land-use and integrated rural development; and consumerism and critical consumer education. An entire section of the book is devoted to a number of (...) reflective case studies of people, organizations and communities using forms of social learning in moving towards sustainability. 'This book brings together a range of ideas, stories, and discussions about purposeful learning in communities aimed at creating a world that is more sustainable than the one currently in prospect....The book is designed to expand the network of conversations through which our society can confront various perspectives, discover emerging patterns, and apply learning to a variety of emotional and social contexts.' From the Foreword by Fritjof Capra, co-founder of the Center of Ecoliteracy. 'Joining what is so clear and refreshing in this book with the larger movements toward a critically democratic and activist education that is worthy of its name, is but one step in the struggle for sustainability. But it is an essential step if we are to use the insights that are included in this book.' From the Afterword by Michael Apple, author of 'Educating the ""Right"" Way: Markets, Standards, God, and Inequality'.". (shrink)

This paper considers a possible national cultural and scientific synthesis which failed to take place: namely the integration of the Central European theoretical physicist Erwin Schrödinger into the primarily experimental orientations of the Oxford physics of the 1930s. We also consider the effect of the Oxford social and intellectual atmosphere generally, incluing the persistence of previous traditions which undervalued Science relative to the Arts, and University research relative to tutorial provision in the Colleges. The Oxford situation is then briefly contrasted (...) to that which Schrödinger later found in Dublin between 1939 and 1956, and which was to have a significantly more productive outcome. (shrink)

Rhetorica approaches armed, sword drawn, announcing the persuasive allure of violence. Whether with real or metaphorical weapons people can be "terrifying and eloquent," to borrow a phrase from Philippe-Joseph Salazar's Words Are Weapons: Inside ISIS's Rhetoric of Terror. The iconic image of Rhetorica's sword emerged from the early modern era of European rhetorical thinking, but the image is one with the violent symbolism that has been attached to rhetoric throughout its history and across cultures. The Greco-Roman rhetorical tradition abounds with (...) examples, deriving in part from the Aristotelian observation that fear can be manipulated for persuasive purposes... (shrink)

Brian Cutter (Analysis 77: 278-287, 2017) argues that one of the most prominent versions of the consequence argument—viz., Peter van Inwagen’s (An Essay on Free Will. Oxford University Press, 1983) ‘Third Formal Argument’—does not support an incompatibility thesis that every paradigmatic compatibilist would reject. Justin Capes (Thought 8: 50-56, 2019) concedes Cutter’s conclusion concerning van Inwagen’s Third Formal Argument and tries to meet the important challenge that Cutter issues at the end of his paper—viz., articulate a promising version of the (...) consequence argument whose conclusion is an incompatibility thesis that every paradigmatic compatibilist would reject. After arguing that Capes’s response to Cutter’s challenge fails, I meet Cutter’s challenge by presenting and discussing a version of the consequence argument that focuses on ordinary human agents in circumstances that are ordinary for human agents. (shrink)

In this paper I attempt to show, by considering a number of sources, including Wittgenstein, Sartre, Thomas Nagel and Spinoza, but also adding something crucial of my own, that it is impossible to construe the subject of experience as an object among other objects in the world. My own added argument is the following. The subject of experience cannot move in time along with material events and processes or it could not be aware of the passage of time, hence neither (...) of change nor of motion. The subject cannot therefore be identified with any neural process, function, or location since whatever goes on in the CNS is necessarily objective and part of the temporal flux. However this does not imply any form of dualism for experiences exist only for the subject whose experiences they are and hence they have no objective reality. (shrink)

Lorazepam has been repeatedly shown to induce memory impairments. The effects of this benzodiazepine on the processes involved in the strategic regulation of memory accuracy have not as yet been explored. An experimental procedure that delineates the role of monitoring and control processes was used. Fifteen lorazepam and 15 placebo subjects were examined using a semantic memory task that combined both a forced- and a free-report option and a no-incentive and an incentive condition. Memory accuracy was lower in the lorazepam (...) than in the placebo group. Lorazepam impaired control sensitivity (the extent to which volunteering of answers is affected by the confidence judgments). While the absolute aspect of monitoring was impaired (calibration scores), both the discriminative aspect (the ability to distinguish between correct and incorrect answers) and the response criterion setting (the confidence threshold set for volunteering a report) were spared. The pharmacological dissociation between monitoring effectiveness and control sensitivity indicates that these two components involve distinct processes. (shrink)